The two teams have met 10 times in the regular season in a series that dates back to 1970, the year of the AFL-NFL merger.
The Packers have won six straight and nine of the last 10 meetings, including a 6-0 mark in San Diego. Green Bay's only loss in the city came in Super Bowl XXXII to the Denver Broncos.
The Chargers were the hosts for the Packers' first-ever appearance on Monday Night Football, on Oct. 12, 1970. The Packers won, 22-20, on a 14-yard Dale Livingston field goal with 3:39 remaining.
Their second meeting, at Lambeau Field in 1974, was won by the Packers, 34-0, and became Dan Devine's final victory in his four-year tenure as Green Bay head coach.
One of the more bizarre contests in Packers history was played in San Diego on Sept. 14, 1978. With a temperature of 102 degrees at kickoff (tied for the highest in Packers history), the teams combined for 18 sacks, including 10 by the Chargers. The Packers also created 11 turnovers - five interceptions (four by Willie Buchanon to tie a league record) and six fumble recoveries - in a 24-3 Green Bay victory.